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. 2017 Oct;58(10):1553–1559. doi: 10.2967/jnumed.117.189944

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© 2017 by the Society of Nuclear Medicine and Molecular Imaging.

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FIGURE 5. — The IEDDA ligation (A); the 2 components of IEDDA-based pretargeting system: a TCO-bearing immunoconjugate and a tetrazine-modified radioligand (B); SPECT/CT image of an LS174T tumor-bearing mouse pretargeted with CC49-TCO and ¹¹¹In-DOTA-tetrazine (reprinted with permission of reference (34)) (C); and a longitudinal study of normalized tumor volume in mice bearing BxPC3 pancreatic ductal adenocarcinoma xenografts treated with a PRIT regimen composed of 5B1-TCO and ¹⁷⁷Lu-DOTA-PEG₇-tetrazine (reprinted with permission of (41)) (D).