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. 2017 Oct;58(10):1560–1566. doi: 10.2967/jnumed.117.193268

FIGURE 4.

FIGURE 4.

Ex vivo biodistribution of 111In-DTPA-anti-PD-L1 at 24 h (A) and 72 h (C) after injection in C57BL/6 mice bearing B16F10 tumors, and selected organs having significant differences in uptake between doses administered at 24 h (B) and 72 h (D). Dose 1: specific activity, 4.4–5.6 MBq/nmol; protein concentration, 0.5–0.6 mg/kg. Dose 2: specific activity, 2.8 MBq/nmol; protein concentration, 1.0 mg/kg. Dose 3: specific activity, 0.9 MBq/nmol; protein concentration, 3.0 mg/kg. Dose 4: specific activity, 0.6 MBq/nmol; protein concentration, 5.0 mg/kg. Dose 5: specific activity, 0.3 MBq/nmol; protein concentration, 10 mg/kg. *P ≤ 0.05. **P ≤ 0.01. ***P ≤ 0.001. ****P ≤ 0.0001.