FIGURE 1.
Evaluation of 6″-18F-fluoromaltotriose in bacterial cultures and in mice. (A) Uptake of 6″-18F-fluoromaltotriose in indicated strains of bacteria for 30 min. (B) Three-dimensional color map from small-animal PET/CT scan of representative nude mouse with E. coli infection in its right thigh 24 h after infection and 1 h after intravenous injection of 7.4 MBq of 6″-18F fluoromaltotriose. Also seen in image is bladder (BL) and kidneys (K). Yellow arrow highlights site of infection. (C) Uptake of 6″-18F-fluoromaltotriose in E. coli versus mammalian cancer cell lines HCC1806 and HCC827. Error bars are SD of means of triplicate samples.