Figure 10.

Space-time plots of action potential propagation in a one-dimensional (1D) transmural ventricular cable at different pacing cycle lengths (PCL). At PCL of 1,000 ms, no conduction block is shown. At PCL of 370 ms, unidirectional conduction block occurs under the R858H condition. When the PCL is decreased, unidirectional conduction block can occur under other conditions. The maximum PCL (MPCL) that produced unidirectional conduction block for G1783C, wild-type (WT), P381S, M456I, A582D, and H858R is 350, 352, 354, 356, 365, and 370 ms, respectively.