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. 2017 Oct 4;8:710. doi: 10.3389/fphar.2017.00710

FIGURE 1.

FIGURE 1

Buspirone counteracted MK-801-induced TOR memory impairment in WT mice. (A) Cartoon illustrating the TOR test and the schedule of treatment. Buspirone (Bus, 3 mg⋅kg-1, i.p.) or vehicle (Veh), clozapine (Clo, 1 mg⋅kg-1, i.p.) or Veh and MK-801 (0.1 mg⋅kg-1, i.p.) or Veh were injected 45, 30, and 20 min respectively, before the sample phase 2. (B,C) Discrimination ratio (DR) displayed by Veh + Veh (n = 10), Veh + MK-801 (n = 10), Bus + MK-801 (n = 9), Clo + MK-801 (n = 9), Bus + Veh (n = 8), Clo + Veh (n = 5) WT mice during the test phase. Data are shown as mean ± SEM. DR [(less recently experienced object exploration time - more recently experienced object exploration time)/total exploration time]. ∗∗∗p < 0.001 vs. Veh + Veh WT mice; ††p < 0.01 and †p < 0.05 vs. Veh + MK-801 WT mice (One-way ANOVA and Newman–Keuls post hoc test).