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. 2017 Oct 4;8:710. doi: 10.3389/fphar.2017.00710

FIGURE 3.

FIGURE 3

Buspirone blocked MK-801-induced PPI disruption in WT mice. Buspirone (Bus, 3 mg⋅kg-1, i.p.) or vehicle (Veh), clozapine (Clo, 1 mg⋅kg-1, i.p.) or Veh and MK-801 (0.1 mg⋅kg-1, i.p.) or Veh were injected 45, 30, and 20 min before the PPI test, respectively. (A,B) Animal movements displayed by Veh + Veh (n = 10), Veh + MK-801 (n = 10), Bus + MK-801 (n = 9), Clo + MK-801 (n = 8), Bus + Veh (n = 13), Clo + Veh (n = 8) WT mice. (C,D) PPI% displayed by the same WT mice. Data are shown as mean ± SEM. ∗∗p < 0.01,∗p < 0.05 vs. Veh + Veh WT mice; †p < 0.05 vs. Veh + MK-801 WT mice; (Two-way ANOVA with or without repeated-measures and Newman–Keuls post hoc test).