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. 2017 May 11;19(10):1105–1117. doi: 10.1038/gim.2017.37

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Functional data: Sherloc criteria and decision tree. Functional evidence is evaluated based on the type of experiment performed and the relevance and validity of the assay. Clinical Laboratory Improvement Amendments–generated biochemical data from affected individuals are also considered a type of in vivo functional experiment, although this evidence type is usually used to augment the value of a case report.