Table 1.
Applications | Population/Animal models | Radioligand | Main findings | Ref. |
---|---|---|---|---|
Preclinical | (i) TSPO PET on day 8 after DSS- and TNBS-induced IBD in rats (ii) 6 rats were followed up over 22 days |
18F-DPA-714 | (i) Significantly increased tracer uptake in the rat colon in both groups, DSS and TNBS, compared to controls (ii) Increased tracer binding until day 8/10 then tracer uptake decreased slowly |
Bernards et al. (2014) [25] |
DSS, dextran sodium sulfate; IBD, inflammatory bowel disease; TNBS, trinitrobenzenesulfonic acid.