| Survivin |
Inhibitor of apoptosis |
Survivin 2B with pro-apoptotic properties |
Down regulated |
Breast carcinoma and late stage or metastatic gastric cancer |
[176, 177] |
| VEGF |
Role in angiogenesis |
Isoforms lacking exon 6 |
Upregulated |
Non-small cell lung cnacer |
[178] |
| Cathepsin B |
Role in the development and progression of cancers |
Certains isoforms |
Overexpressed |
Colon cancer |
[179] |
| FHIT |
Tumour suppressor |
Aberrant transcripts |
Aberrant expression |
Gastric, cervical, thyroid and testicular germ-cell tumours |
[180-185] |
| Actinin 4 |
Actin-binding protein |
Variant Va, a mutually exclusive splice variant where exon 8 is replaced by a new exon of the same size that exists in intron 8 |
Aberrant expression of the splice isoform |
Small cell lung cancer |
[186] |
| AIB1 |
Hormone coactivator |
Isoform lacking exon 3 |
Aberrant expression |
Breast cancer |
[187] |
| RON |
Tyrosine kinase receptor |
RonΔ165 RonΔ160 RonΔ155 |
Overexpressed |
Colorectal carcinoma |
[188, 189] |
