Table 1.
Clinical trials on intensive versus conventional glycemic control and most outstanding outcomes. We highlight the analysis of the mortality discriminated according to the presence or absence of previous diabetes mellitus
| Clinical trial | Study population | Patients with DM (%) | Target range (mg/dL) Intensive versus conventional group |
Mean glycemia (mg/dL) Intensive versus conventional group |
Mortality (%) Intensive/conventional group |
Other results (Intensive versus conventional group) |
|---|---|---|---|---|---|---|
| van den Berghe et al.(1) | Surgical (n = 1548) |
204 (13.2) | 80 - 110 180 - 200 | 103 153 | Overall (4.6/8.0) (p = 0.04) Without DM (4.7/8.4) With DM (4.0/5.8) |
Lower incidence of bacteremia (4.2% versus 7.8%, p = 0.003); TRR (4.8% versus 8.2%, p = 0.007); PNP (28.7% versus 57.9%, p = 0.001) VM (d) (10 versus 12, p = 0.006) |
| van den Berghe et al.(27) | Medical (n = 1200) |
203 (16.9) | 80 - 110 180 - 200 | 111 153 | Overall (24.2/26.8) (p = 0.31) Without DM (36.8/40.9) With DM (39.6/35.0) |
Shorter MV time (HR 1.21, 95%CI 1.02 - 1.44, p = 0.03); ARF (5.9% versus 8.9%, p = 0.04); Staging in ICU (HR 1.15, 95% CI 1.01-1.32, p = 0.04) |
| NICE-SUGAR(4) | Medical-surgical (n = 6104) |
1211 (20.1) | 80 - 108 < 180 | 118 145 | Overall (27.5/24.9) (p = 0.02) Without DM (26.5/24.2) With DM (31.7/27.7) |
Severe hypoglycemia (6.8% versus 0.5%, p = 0.001) |
| Arabi et al.(28) | Medical-surgical (n = 523) | 208 (39.8) | 80 - 110 180 - 200 | 115 171 | Overall (13.5/17.1) (p = 0.70) Without DM (13.8/14.2) With DM (12.9/20.3) |
Hypoglycemia (28.6% versus 3.1%, p = 0.0001) |
| De la Rosa et al.(29) | Medical-surgical (n = 504) |
61 (12.1) | 80 - 110 180 - 200 | 117 149 | Overall (36.6/32.4) With DM (37.5/31.0) |
Severe hypoglycemia (8.3% versus 0.8%, p = 0.001) |
| Brunkhorst et al.(3) | Sepsis/septic shock (n = 488) |
163 (30.4) | 80 - 110 180 - 200 | 112 151 | 24.7 versus 26.0 (p = 0.74) |
Severe hypoglycemia (17.0% versus 4.1%, p = 0.001) |
| Preiser et al.(2) | Medical-surgical (n = 1078) |
203 (18.8) | 80 - 110 140-180 | 118 145 | 17.2 versus 15.3 (p = 0.41) |
Severe hypoglycemia (8.7% versus 2.7%, p = 0.0001) |
| Kalfon et al.(30) | Medical-surgical (n = 2684) |
536 (20.2) | 80 - 110 < 180 | 115 126 | 32.3 versus 34.1 (p = 0.32) |
Severe hypoglycemia 13.2% versus 6.2%, p = 0.001) |
DM - diabetes mellitus; HR - hazard ratio; CI - confidence interval; IRA - acute renal injury; TRR - renal replacement therapy; ICU - intensive care unit; VM - mechanical ventilation.