Table 5.
Significant canonical pathways identified by Ingenuity Pathway Analysis (IPA) in HMECs after 24 h treatment with LPS.
| Ingenuity canonical pathways | −log(P value) |
|---|---|
| Role of IL-17F in allergic inflammatory airway diseases | 7.1 |
| Role of IL-17A in arthritis | 5.7 |
| Agranulocyte adhesion and diapedesis | 5.7 |
| Granulocyte adhesion and diapedesis | 5.4 |
| Role of IL-17A in psoriasis | 4.9 |
| Role of hypercytokinemia/hyperchemokinemia in the pathogenesis of influenza | 4.6 |
| Role of macrophages, fibroblasts, and endothelial cells in rheumatoid arthritis | 4.6 |
| Communication between innate and adaptive immune cells | 4.5 |
| Differential regulation of cytokine production in macrophages and T helper cells by IL-17A and IL-17F | 4.3 |
| HMGB1 signaling | 4.2 |
| Differential regulation of cytokine production in intestinal epithelial cells by IL-17A and IL-17F | 4.0 |
| Role of cytokines in mediating communication between immune cells | 3.5 |
| Glucocorticoid receptor signaling | 3.5 |
| Atherosclerosis signaling | 3.4 |
| Retinol biosynthesis | 3.4 |
| Hepatic fibrosis/hepatic stellate cell activation | 3.0 |
| Acute-phase response signaling | 2.9 |
| IL-17 signaling | 2.8 |
| Graft-versus-host disease signaling | 2.8 |
| IL-17A signaling in fibroblasts | 2.6 |
| Hematopoiesis from pluripotent stem cells | 2.5 |
| Dendritic cell maturation | 2.5 |
| TREM1 signaling | 2.4 |
| IL-17A signaling in gastric cells | 2.3 |
| IL-17A signaling in airway cells | 2.3 |
| The visual cycle | 2.3 |
| Role of pattern recognition receptors in recognition of bacteria and viruses | 2.2 |
| Altered T cell and B cell signaling in rheumatoid arthritis | 2.2 |
| Role of osteoblasts, osteoclasts, and chondrocytes in rheumatoid arthritis | 2.0 |
| Systemic lupus erythematosus signaling | 2.0 |
| Activation of IRF by cytosolic pattern recognition receptors | 1.9 |
| Role of MAPK signaling in the pathogenesis of influenza | 1.9 |
| Hepatic cholestasis | 1.9 |
| LXR/RXR activation | 1.9 |
| Retinoate biosynthesis I | 1.8 |
| Bile acid biosynthesis, neutral pathway | 1.8 |
| Methylglyoxal degradation III | 1.8 |
| Airway pathology in chronic obstructive pulmonary disease | 1.8 |
| IL-6 signaling | 1.6 |
| Crosstalk between dendritic cells and natural killer cells | 1.5 |
| Triacylglycerol degradation | 1.5 |
| Induction of apoptosis by HIV1 | 1.5 |
| Cholecystokinin/gastrin-mediated signaling | 1.5 |
| OX40 signaling pathway | 1.5 |
| Chemokine signaling | 1.4 |
| Role of tissue factor in cancer | 1.4 |
| Antigen presentation pathway | 1.3 |
| PPAR signaling | 1.3 |