Figure 7.

Effects of Y-0452 on ERG responses and retinal cell death in STZ-induced diabetic rats. Rats with 2 months of diabetes and treated with Y-0452 for 3 weeks were used for ERG recording and retinal DNA fragmentation ELISA. (A–D) Scotopic and photopic ERG A and B wave amplitudes in the indicated groups (n = 6; *P < 0.05, **P < 0.01). (E) Quantification of retinal DNA fragmentation, reflective of total retinal apoptosis, in the retina of nondiabetic and STZ-induced diabetic rats treated with Y-0452 and vehicle (n = 6; *P < 0.05, **P < 0.01, 2-way ANOVA).