Figure 5.
LDHA was associated with changes in EMT markers induced by TOP1MT silencing (A) mRNA and (B) protein expression of vimentin, fibronectin, and E-cadherin in BGC-823 and SGC-7901 cells transfected with shTOP1MT or the scramble control (ShNC) were analyzed by RT-PCR and Western blotting, respectively. (C and D) BGC-823 and SGC-7901 cells infected with SiTOP1MT or inhibited by oxamate sodium were subjected to RT-PCR (C) and Western blotting (D) for detection of vimentin, fibronectin, and E-cadherin mRNA and protein expression, respectively. *P < 0.05 in comparisons of the ShTOP1MT-/SiTOP1MT-transfected groups with the ShNC or SiNC group. # P < 0.05 in comparisons of the SiTOP1MT group and the SiTOP1MT with oxamate group.