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. 2017 Jul 10;292(40):16498–16510. doi: 10.1074/jbc.M117.791731

Figure 6.

Figure 6.

Impact of target cell chemokine receptor levels on CoRA/FI synergy. A, titration of CoRA TAK-779 against EnvBaL-mediated HIV-1 entry into JC.53 (high CCR5, filled squares) and JC.10 (low CCR5, open squares) target cells. The measured IC50 values were 59 ± 3.4 and 3.3 ± 0.31 nm, respectively. B, C37 titration of EnvBaL on the two cell lines. The measured IC50 values were 15 ± 2.6 and 1.3 ± 0.15 nm, respectively. C, C37 titrations of EnvBaL on JC.53 target cells (high CCR5) performed in the absence (black) and presence of 25 (red), 50 (green), and 100 nm (blue) TAK-779. D, C37 titrations of EnvBaL on JC.10 target cells (low CCR5) performed in the absence (black) and presence of 2.5 (red), 5 (green), and 10 nm (blue) TAK-779. E and F, IC50 values for C37 (E) and 5HWT (F) as a function of TAK-779 concentration for EnvBaL on JC.53 (high CCR5, filled squares) and JC.10 (low CCR5, open squares). G and H, C37 IC50 values as a function of TAK-779 concentration for EnvJRFL (G) and EnvH5 (H) on the two cell lines.