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Structure of NGF. A, crystal structure of the NGF dimer (PDB ID: 1SG1). The cysteine knot is highlighted in yellow. B, schematic representation of the translation product of the NGF gene. Residues in the signal and the pro-part of proNGF are by convention assigned negative numbers (21). The connectivity of the three cysteine bonds in the mature part is shown. White bar, signal peptide of NGF; light gray bar, pro-part of NGF; dark gray bar, mature NGF.
