Table 4. The cumulative number of malaria infections recorded from birth to 12 months of age.
| Malaria type | 0–12 months | 0–6 months | 6–12 months | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| R435, N (rate) | H435, N (rate) | IRR [CI] | p-Value | R435, N (rate) | H435, N (rate) | IRR [CI] | p-Value | R435, N (rate) | H435, N (rate) | IRR [CI] | p-Value | |
| Symptomatic malaria | 205 (0.54) | 44 (0.36) | 0.68 [0.51, 0.91] | 0.010 | 55 (0.15) | 14 (0.12) | 0.88 [0.53, 1.47] | 0.631 | 150 (0.40) | 30 (0.25) | 0.61 [0.43, 0.87] | 0.007 |
| Asymptomatic malaria | 157 (0.42) | 44 (0.34) | 0.95 [0.68, 1.32] | 0.760 | 58 (0.15) | 22 (0.18) | 1.16 [0.70, 1.91] | 0.570 | 99 (0.26) | 27 (0.22) | 0.83 [0.53, 1.28] | 0.404 |
Women homozygous for IgG3-R435, N = 377; women with IgG3-H435, N = 120. Incidence rate ratios (IRRs) adjusted for placental malaria infection and individual malaria exposure. Symptomatic malaria defined as fever > 37.5°C and >2,500 parasites/μl of blood. In this model (0–12 months), placental malaria was associated with a 52% increased risk of clinical malaria (incidence rate ratio [IRR] = 1.52 [95% CI 1.05, 2.19], p = 0.025), and infant malaria exposure was associated with an 8% increased risk of clinical malaria (IRR = 1.08 [95% CI 1.06, 1.11], p < 0.001). p-Values < 0.05 shown in bold.