Table 1. Changes in pain processing.
| MNI coordinates | ||||||
|---|---|---|---|---|---|---|
| Anatomical Region | L/R | cluster size | x | y | z | T score |
| (A) placebo > topiramate (Small volume correction of the thalamus) | ||||||
| Thalamus | R | 158 | 4 | -8 | 8 | 4.72 |
| (B) placebo > topiramate (whole brain) | ||||||
| Secondary somatosensory cortex | L | 355 | -36 | -32 | 26 | 6.15 |
| Anterior cingulate cortex | R | 246 | 8 | -2 | 46 | 5.79 |
| Secondary somatosensory cortex / Insula | R | 203 | 48 | -24 | 6 | 4.95 |
| Lateral occipital gyrus | R | 227 | 28 | -68 | 22 | 4.94 |
| Thalamus | R | 217 | 4 | -8 | 8 | 4.72 |
| Anterior cingulate cortex | L | 454 | -2 | 42 | -4 | 4.56 |
Peak coordinates for the contrast placebo > topiramate during nociceptive stimulation: (A) Small volume correction of the thalamus at a threshold of p(FWE) < 0.05 and (B) whole brain contrast placebo > topiramate at a threshold of p(FWE) < 0.05 (cluster level).