Table 2. Top 10 module membership genes.
The module membership of a gene (kME) is the correlation between the gene and the eigengene of the module. For the black, salmon, red and greenyellow modules, we list the top 10 kME genes based on the sum of ranks in the COPDGene and ECLIPSE cohort. The ranks were based on kME. For COPDGene and ECLIPSE, the correlation direction between the gene and the phenotypes are represented by “+” and “-”, if the correlation is significant at α = 0.05.
| Module | Genes | Rank | COPDGene | ECLIPSE | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| COPDGene | ECLIPSE | Sum | FEV1% | FEV1/FVC | Emph. | FEV1% | FEV1/FVC | Emph. | ||
| red 163 genes |
FCGRT | 5 | 4 | 9 | - | - | - | - | ||
| TALDO1 | 8 | 10 | 18 | - | - | |||||
| NFAM1 | 11 | 15 | 26 | - | - | |||||
| TYROBP | 2 | 28 | 30 | - | - | - | - | |||
| PFKFB4 | 18 | 14 | 32 | - | - | - | - | |||
| ZNF467 | 21 | 11 | 32 | - | - | |||||
| FES | 12 | 21 | 33 | - | - | - | - | |||
| CFP | 3 | 32 | 35 | - | - | - | - | |||
| LTBR | 6 | 29 | 35 | - | - | - | - | |||
| TKT | 20 | 17 | 37 | - | - | - | - | |||
| black 163 genes |
KLF12 | 2 | 1 | 3 | + | + | + | |||
| PLEKHA1 | 9 | 2 | 11 | + | + | + | + | |||
| OXCT1 | 10 | 7 | 17 | + | + | + | ||||
| SLAIN1 | 3 | 20 | 23 | + | + | + | + | |||
| PSIP1 | 23 | 3 | 26 | + | + | + | + | |||
| RASGRP1 | 32 | 4 | 36 | + | + | + | + | |||
| CDC42SE2 | 27 | 11 | 38 | + | + | + | + | |||
| DDHD2 | 36 | 12 | 48 | + | + | + | + | |||
| ITK | 25 | 23 | 48 | + | + | + | + | |||
| TC2N | 13 | 37 | 50 | |||||||
| greenyellow 97 genes |
EIF4EBP1 | 7 | 1 | 8 | - | - | ||||
| PYCARD | 2 | 6 | 8 | - | - | - | - | |||
| TMEM205 | 8 | 2 | 10 | - | - | |||||
| FAM127A | 10 | 5 | 15 | - | ||||||
| AGTRAP | 4 | 12 | 16 | - | - | - | - | |||
| AP2S1 | 13 | 3 | 16 | - | ||||||
| KIAA0930 | 5 | 15 | 20 | - | - | - | - | |||
| NRM | 17 | 7 | 24 | - | ||||||
| TSPO | 3 | 22 | 25 | - | - | |||||
| ZNF385A | 9 | 16 | 25 | - | - | |||||
| salmon 68 genes |
IFI35 | 3 | 2 | 5 | - | - | ||||
| XAF1 | 5 | 1 | 6 | - | ||||||
| IFIT3 | 7 | 3 | 10 | - | - | |||||
| HERC5 | 4 | 7 | 11 | |||||||
| RSAD2 | 2 | 9 | 11 | - | - | |||||
| MX1 | 13 | 5 | 18 | |||||||
| IFI6 | 6 | 13 | 19 | - | - | |||||
| UBE2L6 | 1 | 18 | 19 | |||||||
| IFI44L | 9 | 11 | 20 | |||||||
| OASL | 14 | 6 | 20 | - | - | |||||