Table S5.
Comparison of medical resource utilization and costs for GT1 patients
| Resource item | Patients receiving IFN-based therapy (n=17)
|
Theoretical patients receiving SOF/LDV (n=100)
|
||
|---|---|---|---|---|
| Mean number per patient ± SD | Mean cost per patient ± SD | Mean number per patient ± SD | Mean cost per patient ± SD | |
| Blood tests | 18 ± 9.1 | $1943.63 ± 586.47 | 4.16 ± 0.37 | $590.21 ±1 68.75 |
| Ultrasound | 0.06 ± 0.24 | $6.55 ± 26.99 | 0 ± 0 | $0 ± 0 |
| CXR¶ | 0.24 ± 0.44 | $11.09 ± 20.62 | 0.01 ± 0.1 | $0.57 ± 4.72 |
| ECHO | 0.06 ± 0.24 | $13.57 ± 55.94 | 0 ± 0 | $0 ± 0 |
| CT scan | 0.24 ± 0.56 | $68.83 ± 163.93 | 0 ± 0 | $0 ± 0 |
| ECG¶ | 0.18 ± 0.39 | $2.74 ± 6.11 | 0.01 ± 0.1 | $0.16 ± 1.56 |
| Urinalysis | 0.12 ± 0.33 | $2.42 ± 6.82 | 0 ± 0 | $0 ± 0 |
| BMAT | 0.06 ± 0.24 | $5.19 ± 21.40 | 0 ± 0 | $0 ± 0 |
| MRCP | 0.06 ± 0.24 | $26.35 ± 103.66 | 0 ± 0 | $0 ± 0 |
| Stress ECG¶ | 0 ± 0 | $0 ± 0 | 0.01 ± 0.1 | $1.52 ± 15.22 |
| Specialist Referral | 0.80 ± 0.77 | $120.73 ± 134.46 | 0.01 ± 0.1 | $1.51 ± 15.09 |
| Psychiatry | 0.24 ± 0.44 | $61.25 ± 113.81 | 0 ± 0 | $0 ± 0 |
| Dermatology | 0.12 ± 0.33 | $10.06 ± 28.41 | 0 ± 0 | $0 ± 0 |
| Rheumatology | 0.06 ± 0.24 | $8.88 ± 36.60 | 0 ± 0 | $0 ± 0 |
| Gastroenterology | 0.06 ± 0.24 | $8.88 ± 36.60 | 0 ± 0 | $0 ± 0 |
| Cardiology¶ | 0.06 ± 0.24 | $8.88 ± 36.60 | 0.01 ± 0.1 | $1.51 ± 15.09 |
| Hematology | 0.06 ± 0.24 | $8.88 ± 36.60 | 0 ± 0 | $0 ± 0 |
| Endocrinology | 0.06 ± 0.24 | $8.88 ± 36.60 | 0 ± 0 | $0 ± 0 |
| Liver clinic visits | 12.5 ± 4.61 | N/A | 4.16 ± 0.37 | N/A |
| ER presentations | 0.35 ± 0.86 | N/A | 0.01 ± 0.1 | N/A |
| Hospital admissions | 0.07 ± 0.26 | N/A | 0 ± 0 | N/A |
Note: The single serious adverse event (chest pain) for theoretical patients receiving SOF/LDV was predicted to result in an ECG, CXR, stress ECG, and a cardiology referral.
Abbreviations: BMAT, bone marrow aspirate and trephine; CT, computed tomography; CXR, chest x-ray; ECG, electrocardiogram; ECHO, echocardiogram; ER, emergency room; GT1, genotype 1; IFN, interferon; LDV, ledipasvir; MRCP, magnetic resonance cholangiopancreatography; N/A, not applicable; SD, standard deviation; SOF, sofosbuvir.