Table 1.
Overview of theranostic agents
| Theranostic molecule | Iodine | mIBG | SSA | PSMA-ligands | Benzamide/arylcarboxamide |
|---|---|---|---|---|---|
| Target | Thyroid cancer cells | Neurosecretory granules | SSTR, especially the subtype SSTR2 | PSMA | Melanin |
| Planar imaging/SPECT or PET | 131I and 123I | [131I]I-mIBG, [123I]I-mIBG | SSA labeled with indium-111 | [123I]I-MIP-1072 | [123I]I-BA52 |
| 124I | [124I]I-mIBG | [68Ga]Ga-DOTA-TATE | [68Ga]Ga-PSMA-11 | [18F]F-ICF15002 | |
| [68Ga]Ga-DOTA-TOC | [68Ga]Ga-PSMA-617 | ||||
| [68Ga]Ga-DOTA-NOC | |||||
| Therapeutic agent | 131I | [131I]I-mIBG | [177Lu]Lu-DOTA-TATE | [177Lu]Lu-J591 | [131I]I-BA52 |
| [177Lu]Lu-DOTA-TOC | [90Y]Y-J591 | [131I]I-ICF15002 | |||
| [90Y]Y-DOTA-TOC | [131I]I-MIP-1095 | ||||
| [90Y]Y-DOTA-TATE | [177Lu]Lu-PSMA-617 | ||||
| Indication | Thyroid cancer | Neuroblastomas, pheochromocytomas, paragangliomas, medullary thyroid carcinomas, and other NEN | NEN, especially GEP-NEN | Metastatic prostate cancer | Metastatic melanoma |
Abbreviations: mIBG, metaiodobenzylguanidine; SSA, somatostatin analogs; SSTR, somatostatin receptors; NEN, neuroendocrine neoplasia; GEP, gastroenteropancreatic system; SPECT, single photon emission computed tomography; PET, positron emission tomography.