Table 1.

SGLT2/SGLT1 selectivity of main SGLT inhibitors33–37

Molecule	SGLT2 (IC50 nM)	SGLT1 (IC50 nM)	SGLT2 selectivity over SGLT1
Empagliflozin	3.1	8,300	~2,500-fold
Ertugliflozin	0.87	1,960	~2,000-fold
Dapagliflozin	1.2	1,400	~1,200-fold
Canagliflozin	2.7	710	~250-fold
Sotagliflozin	1.8	36	~20-fold
Phlorizin	2,800	4,200	~1.5-fold

Abbreviations: IC50, half-maximal inhibitory concentration; SGLT, sodium-glucose cotransporter.