Table 4.

Summary of important TF‐associated miRNAs with survival after diagnosis with colon cancer

miRNA	Transcription Factors a	Factor 1	Factor 2	Factor 3	Factor 4	Factor 5	Factor 6
hsa‐let‐7i‐5p	ATF1, BACH1, CTCF, GABPA, RBBP5, SMARCC1, TCF12, ZBTB33	0.32	−0.10	0.56	0.58	0.15	−0.11
hsa‐miR‐10a‐5p	BACH1, RBBP5, SMARCC1, TCF12, ZBTB33	0.32	−0.07	0.23	0.53	0.24	−0.11
hsa‐miR‐124‐3p	ATF1, ELK1, PHF8, SP1	0.03	0.57	−0.08	−0.11	0.12	−0.24
hsa‐miR‐1258	ATF1, ELK1, SMARCC1	−0.04	0.84	0.00	−0.04	0.04	−0.06
hsa‐miR‐133b	GABPA, HMGN3	0.11	0.11	0.02	0.00	0.79	−0.11
hsa‐miR‐145‐5p	CTCF, ELF1, GABPA, HDAC6, HMGN3, MEF2A, NFYA, RBBP5, SMARCC2, SP1, TCF12	−0.08	−0.15	0.23	0.30	0.77	−0.02
hsa‐miR‐17‐5p	CTCF, RBBP5, SMARCC1, TCF12, ZBTB33	0.85	−0.03	0.21	0.31	0.00	0.00
hsa‐miR‐1915‐5p	BACH1, MEF2A, NFYA, PHF8, SMARCC1, SP1	−0.11	0.63	−0.03	−0.15	−0.05	0.55
hsa‐miR‐193b‐3p	ATF1, BACH1, CTCF, ELF1, GABPA, HMGN3, MEF2A, NFYA, RBBP5, SMARCC1, SMARCC2, TCF12, ZBTB33	0.19	−0.05	0.61	0.09	0.45	0.11
hsa‐miR‐199a‐3p	ATF1, BACH1, ELF1, GABPA, MEF2A, RBBP5, SMARCC1, TCF12, ZBTB33	0.29	−0.02	0.73	0.32	0.30	−0.01
hsa‐miR‐199a‐5p	ATF1, BACH1, CTCF, ELF1, GABPA, HMGN3, MEF2A, RBBP5, SMARCC1, TCF12, ZBTB33	0.26	−0.01	0.71	0.22	0.41	0.04
hsa‐miR‐20a‐5p	CTCF, RBBP5, SMARCC1, TCF12, ZBTB33	0.84	−0.07	0.21	0.33	0.02	0.00
hsa‐miR‐20b‐5p	CTCF, RBBP5, SMARCC1, TCF12, ZBTB33	0.87	0.02	0.10	0.12	0.12	0.09
hsa‐miR‐214‐3p	ATF1, GABPA	0.14	0.09	0.67	0.12	0.47	0.08
hsa‐miR‐21‐3p	RBBP5, SMARCC1, TCF12	0.41	0.00	0.65	0.03	−0.03	−0.07
hsa‐miR‐21‐5p	BACH1, CTCF, GABPA, RBBP5, SMARCC1, TCF12, ZBTB33	0.39	−0.14	0.47	0.65	0.03	−0.07
hsa‐miR‐221‐3p	RBBP5, SMARCC1, TCF12, ZBTB33	0.67	−0.03	0.34	0.05	0.21	0.04
hsa‐miR‐222‐3p	BACH1, GABPA, RBBP5, SMARCC1, TCF12	0.41	−0.05	0.55	0.16	0.04	−0.12
hsa‐miR‐23a‐3p	BACH1, CTCF, GABPA, MEF2A, RBBP5, SMARCC1, TCF12, ZBTB33	0.44	−0.16	0.38	0.68	0.27	−0.08
hsa‐miR‐24‐3p	BACH1, CTCF, GABPA, MEF2A, RBBP5, SMARCC1, TCF12, ZBTB33	0.40	−0.19	0.34	0.65	0.28	−0.10
hsa‐miR‐25‐3p	CTCF, RBBP5, SMARCC1, TCF12, ZBTB33	0.76	0.02	0.40	0.12	0.09	−0.10
hsa‐miR‐27a‐3p	ATF1, BACH1, CTCF, GABPA, RBBP5, SMARCC1, TCF12, ZBTB33	0.56	−0.05	0.51	0.50	0.15	−0.06
hsa‐miR‐29a‐3p	BACH1, CTCF, RBBP5, SMARCC1, TCF12, ZBTB33	0.61	−0.12	0.34	0.54	0.06	−0.12
hsa‐miR‐29b‐3p	CTCF, RBBP5, SMARCC1, TCF12, ZBTB33	0.65	−0.04	0.39	0.32	0.08	−0.07
hsa‐miR‐3181	BACH1, MEF2A, NFYA, PHF8, SMARCC1, SP1	−0.09	0.66	−0.03	−0.23	−0.07	0.27
hsa‐miR‐331‐3p	ATF1, BACH1, CTCF, GABPA, RBBP5, SMARCC1, TCF12, ZBTB33	0.37	−0.10	0.51	0.23	0.25	−0.13
hsa‐miR‐34a‐5p	ATF1, BACH1, CTCF, GABPA, RBBP5, SMARCC1, TCF12, ZBTB33	0.43	0.02	0.64	0.29	0.10	−0.07
hsa‐miR‐3651	CTCF, RBBP5, SMARCC1, TCF12, ZBTB33	0.60	−0.23	0.09	0.56	−0.04	0.00
hsa‐miR‐425‐5p	RBBP5, SMARCC1, TCF12	0.75	0.08	0.22	−0.10	0.20	−0.10
hsa‐miR‐4469	ATF1, BACH1, ELK1, MEF2A, NFYA, PHF8, SMARCC1, SP1	−0.02	0.77	−0.01	−0.08	0.06	0.13
hsa‐miR‐4492	ATF1, NFYA, SMARCC1, SP1	−0.05	0.64	−0.01	−0.05	−0.05	0.41
hsa‐miR‐4520b‐3p	ATF1, ELK1, SMARCC1	0.06	0.82	0.03	0.01	0.04	−0.02
hsa‐miR‐5008‐3p	BACH1, MEF2A, NFYA, PHF8, SMARCC1, SP1	−0.01	0.40	−0.10	−0.11	0.02	0.59
hsa‐miR‐513c‐3p	ATF1, SMARCC1	0.00	0.80	0.00	0.04	0.02	−0.10
hsa‐miR‐5685	ATF1, BACH1, MEF2A, SMARCC1, SP1	−0.11	0.72	−0.01	0.01	−0.03	0.12
hsa‐miR‐6071	ATF1, BACH1, ELK1, MEF2A, NFYA, PHF8, SMARCC1, SP1	−0.06	0.65	−0.05	−0.17	0.00	0.38
hsa‐miR‐92a‐3p	CTCF, RBBP5, SMARCC1, TCF12, ZBTB33	0.65	−0.35	−0.03	0.46	0.09	0.15
hsa‐miR‐93‐5p	CTCF, RBBP5, SMARCC1, TCF12, ZBTB33	0.80	−0.03	0.32	0.23	0.01	−0.13
hsa‐miR‐99a‐5p	GABPA, HMGN3	0.15	0.05	0.26	0.08	0.76	0.05
hsa‐miR‐99b‐5p	ELF1, GABPA, HMGN3	0.12	0.09	0.20	0.05	0.76	0.02
Eigenvalue		15.36	5.81	3.10	1.38	1.18	1.01
Proportion		0.38	0.15	0.08	0.03	0.03	0.03
HR b		0.78	1.24	1.22	0.93	1.86	0.83
(95% CI)		(0.58, 1.05)	(0.92, 1.67)	(0.91, 1.64)	(0.69, 1.25)	(1.36, 2.54)	(0.62, 1.13)

Bolded values are considered significant.

^aThese TF are displayed because the associated miRNA loaded highly to a factor that was associated with altered CRC survival in the TF‐specific PCA.

^bAdjusted for age, center, and sex.