. 2017 Aug 3;56(11):2512–2526. doi: 10.1002/mc.22698

Table 5.

Summary of important TF‐associated miRNAs with survival after diagnosis with rectal cancer

miRNA	Transcription Factor ^a	Factor 1	Factor 2	Factor 3	Factor 4	Factor 5	Factor 6
hsa‐let‐7i‐5p	BCL11A, BCLAF1, ELK1, GABPA, HDAC6, STAT5A, ZNF263	0.23	0.75	0.14	0.20	0.25	0.08
hsa‐miR‐10a‐5p	ELF1, GABPA, MEF2A, NFYA, SP1	0.39	0.43	0.15	−0.02	0.31	0.38
hsa‐miR‐145‐5p	GABPA, HDAC6	−0.32	0.65	0.03	0.17	0.10	−0.05
hsa‐miR‐146a‐5p	ATF1, BCL11A, BCLAF1, CTCF, ELF1, HDAC6, MEF2A, RBBP5, SMARCC2, STAT5A	0.49	0.08	−0.12	0.23	0.52	−0.07
hsa‐miR‐146b‐5p	BACH1, BCLAF1, GABPA, HDAC6, MEF2A, NFYA, RBBP5, SMARCC1, SMARCC2, SP1, STAT5A, TCF12, ZBTB33	0.17	0.17	−0.14	0.77	0.16	0.02
hsa‐miR‐150‐5p	ATF1, BCL11A, BCLAF1, CTCF, ELF1, HDAC6, MEF2A, NFYA, RBBP5, SMARCC2	0.01	0.23	−0.01	0.01	0.79	−0.15
hsa‐miR‐151a‐3p	ATF1, BACH1, HDAC6, MEF2A, NFYA, RBBP5, SMARCC2, SP1, TCF12, ZBTB33	0.38	0.08	0.17	0.62	−0.14	0.10
hsa‐miR‐17‐5p	ATF1, BACH1, BCL11A, BCLAF1, CTCF, ELF1, GABPA, HMGN3, MEF2A, NFYA, RBBP5, SMARCC1, SMARCC2, SP1, TCF12, ZBTB33	0.76	0.28	0.39	0.00	0.01	0.07
hsa‐miR‐193b‐3p	GABPA, HDAC6, ZNF263	0.13	0.71	−0.01	0.14	0.02	−0.07
hsa‐miR‐196a‐5p	ATF1, NFYA	0.65	−0.12	0.11	0.24	0.10	0.17
hsa‐miR‐199b‐5p	BACH1, GABPA, SMARCC2, TCF12	0.02	0.31	0.01	0.77	0.06	−0.09
hsa‐miR‐203a	ELF1, SP1	0.62	0.06	−0.02	0.26	−0.01	0.25
hsa‐miR‐20a‐5p	ATF1, BACH1, CTCF, ELF1, GABPA, HMGN3, MEF2A, NFYA, RBBP5, SMARCC1, SMARCC2, SP1, TCF12, ZBTB33	0.76	0.28	0.42	−0.02	0.07	0.04
hsa‐miR‐20b‐5p	ATF1, BACH1, CTCF, ELF1, ELK1, GABPA, HDAC6, HMGN3, NFYA, PHF8, RBBP5, SMARCC1, SMARCC2, SP1, TCF12, ZBTB33	0.72	0.12	0.38	0.31	0.01	−0.08
hsa‐miR‐210	ATF1, ELK1, HDAC6, SMARCC1, TCF12, ZBTB33, ZNF263	0.16	0.07	−0.13	−0.01	−0.25	0.74
hsa‐miR‐21‐3p	BACH1, HDAC6, SMARCC2, SP1, TCF12, ZNF263	0.48	0.46	−0.05	−0.02	−0.11	−0.33
hsa‐miR‐21‐5p	GABPA, HDAC6, MEF2A, SMARCC2, TCF12	0.33	0.63	0.28	0.27	0.04	0.19
hsa‐miR‐221‐3p	ATF1, BACH1, CTCF, ELF1, GABPA, NFYA, PHF8, RBBP5, SMARCC1, SP1, TCF12, ZBTB33	0.64	0.38	0.04	0.27	−0.13	−0.06
hsa‐miR‐222‐3p	BACH1, BCL11A, BCLAF1, HDAC6, RBBP5, SMARCC2, SP1, STAT5A, TCF12, ZNF263	0.45	0.61	−0.01	0.04	−0.18	−0.13
hsa‐miR‐23a‐3p	CTCF, ELF1, GABPA, HDAC6, SMARCC2, TCF12	0.31	0.74	0.36	0.19	0.11	0.21
hsa‐miR‐24‐3p	BCL11A, BCLAF1, ELK1, GABPA, HDAC6, ZNF263	0.25	0.77	0.34	0.16	0.09	0.20
hsa‐miR‐25‐3p	ATF1, BACH1, BCL11A, BCLAF1, CTCF, ELF1, GABPA, HDAC6, HMGN3, MEF2A, NFYA, PHF8, RBBP5, SMARCC1, SMARCC2, SP1, TCF12, ZBTB33, ZNF263	0.78	0.33	0.21	−0.02	0.04	0.00
hsa‐miR‐27a‐3p	ATF1, BACH1, BCLAF1, CTCF, ELF1, GABPA, HDAC6, HMGN3, MEF2A, NFYA, RBBP5, SMARCC1, SMARCC2, SP1, TCF12, ZBTB33	0.55	0.64	0.23	0.09	0.10	0.12
hsa‐miR‐29a‐3p	ATF1, BACH1, BCL11A, BCLAF1, CTCF, ELF1, ELK1, GABPA, HDAC6, HMGN3, MEF2A, NFYA, PHF8, RBBP5, SMARCC1, SMARCC2, SP1, TCF12, ZBTB33, ZNF263	0.58	0.42	0.44	0.14	0.21	0.08
hsa‐miR‐29b‐3p	ATF1, BACH1, CTCF, ELF1, GABPA, HMGN3, MEF2A, NFYA, RBBP5, SMARCC1, TCF12, ZBTB33	0.64	0.33	0.26	0.14	0.23	0.06
hsa‐miR‐331‐3p	GABPA, HDAC6, ZNF263	0.28	0.68	0.10	−0.02	0.13	0.04
hsa‐miR‐34a‐5p	BCL11A, BCLAF1, ELF1, ELK1, GABPA, HDAC6, MEF2A, NFYA, PHF8, RBBP5, SMARCC2, SP1, STAT5A, TCF12, ZNF263	0.56	0.55	−0.09	0.10	0.09	−0.08
hsa‐miR‐3651	ATF1, BACH1, BCL11A, CTCF, ELF1, ELK1, GABPA, HDAC6, MEF2A, NFYA, SMARCC1, SMARCC2, SP1, ZBTB33, ZNF263	0.30	0.29	0.64	−0.12	0.15	0.29
hsa‐miR‐424‐3p	BCL11A, ELK1, HDAC6, NFYA, SMARCC2, SP1, ZNF263	0.08	0.00	0.79	0.05	−0.03	−0.14
hsa‐miR‐425‐5p	ATF1, CTCF, ELF1, GABPA, HDAC6, NFYA, RBBP5, SMARCC1, SMARCC2, SP1, TCF12	0.76	0.19	0.03	0.12	0.10	0.13
hsa‐miR‐92a‐3p	ATF1, BACH1, BCL11A, BCLAF1, CTCF, ELF1, ELK1, GABPA, HDAC6, HMGN3, NFYA, RBBP5, SMARCC1, SMARCC2, SP1, TCF12, ZBTB33, ZNF263	0.31	0.22	0.74	−0.05	−0.14	−0.10
Eigenvalue		13.27	2.74	2.09	1.40	1.29	1.11
Proportion		0.41	0.09	0.07	0.04	0.04	0.03
HR ^b		0.51	1.03	0.65	0.63	0.64	2.01
(95% CI)		(0.34, 0.74)	(0.72, 1.48)	(0.45, 0.94)	(0.42, 0.92)	(0.44, 0.91)	(1.33, 3.04)

Bolded values are considered significant.

^{^a}

These TF are displayed because the associated miRNA loaded highly to a factor that was associated with altered CRC survival in the TF‐specific PCA.

^{^b}

Adjusted for age, center, and sex.