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. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: J Glaucoma. 2017 Oct;26(10):851–859. doi: 10.1097/IJG.0000000000000768

Table 4.

4.5mm × 4.5mm Optic Nerve Head Scans: Intra-visit and Inter-visit Reproducibility of Vessel Density*

Healthy Subjects Glaucoma Patients Mean
VD p-
Values		 Healthy vs.
Glaucoma CV p-
Values
Intra-visit Inter-visit Intra-visit Inter-visit
Sector Mean VD of 4 sessions ICC
(95% CI)		 SD
(95% CI)		 CV
(95% CI)		 ICC
(95% CI)		 SD
(95% CI)		 CV
(95% CI)		 Mean VD of 4 sessions ICC
(95% CI)		 SD
(95% CI)		 CV
(95% CI)		 ICC
(95% CI)		 SD
(95% CI)		 CV
(95% CI)		 Intra-visit Inter-visit
wiVD 49.3
(47.8–50.8)		 0.85
(0.76–0.91)		 1.61
(1.31–2.08)		 3.2
(2.6–4.2)		 0.61
(0.51–0.71)		 3.05
(2.49–3.95)		 6.1
(5.0–8.0)		 43.6
(42.0–45.2)		 0.93
(0.86–0.97)		 1.39
(1.15–1.76)		 3.2
(2.6–4.0)		 0.89
(0.81–0.94)		 1.86
(1.54–2.35)		 4.2
(3.5–5.3)		 0.022 0.897 0.027
pfVD 52.0
(50.3–53.7)		 0.46
(0.36–0.57)		 2.95
(2.40–3.81)		 5.6
(4.6–7.3)		 0.25
(0.17–0.35)		 4.70
(3.83–6.08)		 9.0
(7.3–11.7)		 47.1
(45.4–48.8)		 0.91
(0.84–0.96)		 1.55
(1.28–1.96)		 3.3
(2.7–4.1)		 0.75
(0.66–0.83)		 2.94
(2.43–3.71)		 6.2
(5.1–7.8)		 0.033 0.002 0.029
4 Parafoveal Quadrants
T 52.9
(50.7–55.1)		 0.00
(0.00–0.03)		 4.99
(4.07–6.46)		 9.4
(7.6–12.2)		 0.00
(0.00–0.03)		 6.75
(5.50–8.73)		 12.7
(10.3–16.5)		 47.4
(45.6–49.1)		 0.82
(0.74–0.89)		 2.34
(1.94–2.96)		 4.9
(4.0–6.2)		 0.67
(0.57–0.76)		 3.60
(2.98–4.54)		 7.5
(6.2–9.6)		 0.006 <0.001 0.003
S 52.0
(50.0–54.0)		 0.53
(0.42–0.63)		 4.21
(3.44–5.45)		 8.1
(6.6–10.5)		 0.53
(0.42–0.63)		 4.21
(3.44–5.45)		 8.1
(6.6–10.5)		 47.0
(45.2–48.9)		 0.83
(0.75–0.90)		 2.49
(2.06–3.14)		 5.2
(4.3–6.6)		 0.73
(0.63–0.81)		 3.43
(2.84–4.33)		 7.2
(6.0–9.2)		 0.110 0.013 0.504
N 51.8
(49.9–53.8)		 0.19
(0.12–0.29)		 3.59
(2.92–4.64)		 6.9
(5.6–8.9)		 0.08
(0.03–0.15)		 5.84
(4.76–7.56)		 11.2
(9.1–14.6)		 47.4
(45.5–49.2)		 0.81
(0.72–0.88)		 2.27
(1.88–2.87)		 4.8
(3.9–6.0)		 0.58
(0.47–0.67)		 4.03
(3.33–5.09)		 8.5
(7.0–10.7)		 0.033 0.030 0.091
I 51.2
(49.4–53.1)		 0.60
(0.49–0.69)		 3.43
(2.80–4.44)		 6.6
(5.4–8.6)		 0.51
(0.41–0.61)		 4.07
(3.32–5.27)		 7.9
(6.4–10.3)		 46.6
(44.8–48.4)		 0.86
(0.78–0.92)		 2.35
(1.95–2.97)		 5.0
(4.1–6.3)		 0.83
(0.74–0.90)		 2.64
(2.19–3.34)		 5.6
(4.6–7.1)		 0.058 0.086 0.043
Fovea 32.1
(30.1–34.1)		 0.70
(0.60–0.78)		 3.26
(2.66–4.22)		 10.1
(8.2–13.1)		 0.54
(0.44–0.64)		 4.51
(3.68–5.84)		 14.0
(11.4–18.3)		 30.6
(28.6–32.5)		 0.92
(0.85–0.96)		 1.90
(1.57–2.40)		 6.2
(5.1–7.8)		 0.90
(0.82–0.95)		 2.22
(1.84–2.81)		 7.2
(6.0–9.2)		 0.675 0.005 <0.001
*

VD = vessel density; CV = coefficient of variation; ICC = intraclass correlation; SD = standard deviation; CI = confidence interval; wiVD = whole image vessel density; pfVD = parafoveal vessel density; T = temporal; S = superior; N = nasal; I = inferior