Table 4.

Among patients with localized (stage I–II) and regional disease (stage III), separately, association between sex and death due to melanoma, stratified by melanoma characteristics

Characteristic	Among patients with localized disease			Among patients with regional disease
	No. of deaths due to melanoma/no. of patients	HR (95% CI) males versus females	P‐value	No. of deaths due to melanoma/no. of patients	HR (95% CI) males versus females	P‐value
Breslow depth (mm), n (%)
0.01–0.99 mm	1255/63,285	1.76 (1.57, 1.98)	<0.001	375/1540	1.65 (1.32, 2.05)	<0.001
1.00–2.00 mm	1179/12,187	1.57 (1.39, 1.78)	<0.001	587/2158	1.42 (1.20, 1.68)	<0.001
2.01–4.00 mm	1023/5194	1.46 (1.28, 1.66)	<0.001	936/2662	1.39 (1.21, 1.59)	<0.001
>4.00 mm	436/1780	1.59 (1.29, 1.96)	<0.001	1179/2833	1.35 (1.19, 1.52)	<0.001
Unknown	386/9421	1.55 (1.26, 1.90)	<0.001	456/1101	1.16 (0.96, 1.41)	0.13
Histologic subtype, n (%)
Superficial spreading	1259/35,694	1.87 (1.66, 2.10)	<0.001	602/2063	1.73 (1.45, 2.06)	<0.001
Lentigo maligna	173/6508	2.26 (1.54, 3.32)	<0.001	48/175	1.22 (0.65, 2.28)	0.53
Acral lentigonous	89/784	1.50 (0.99, 2.28)	0.06	147/364	1.46 (1.05, 2.04)	0.024
Nodular	865/4559	1.72 (1.48, 1.98)	<0.001	1051/2634	1.40 (1.23, 1.59)	<0.001
NOS	1694/38,169	1.70 (1.54, 1.88)	<0.001	1525/4343	1.25 (1.12, 1.39)	<0.001
Others	199/3154	1.83 (1.35, 2.48)	<0.001	266/1005	1.34 (1.04, 1.73)	0.026
Anatomic site, n (%)
Face/ears	591/10,833	1.69 (1.40, 2.04)	<0.001	318/1152	1.47 (1.14, 1.90)	0.004
Scalp/neck	517/5629	1.38 (1.12, 1.70)	0.003	459/1134	1.09 (0.88, 1.35)	0.45
Trunk	1588/31,276	1.55 (1.39, 1.73)	<0.001	1160/3101	1.39 (1.21, 1.59)	<0.001
Extremities	1560/40,687	1.77 (1.60, 1.96)	<0.001	1456/4556	1.41 (1.27, 1.56)	<0.001
NOS/overlapping	23/443	1.67 (0.69, 4.07)	0.26	246/641	0.95 (0.73, 1.23)	0.68

HR, hazard ratio; CI, confidence interval.