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. 2017 Jun 5;36(40):5576–5592. doi: 10.1038/onc.2017.175

Figure 2.

Figure 2

Impaired autophagy enhances Ras-driven overgrowth of the adult Drosophila eye. (a) Scanning electron micrographs of ey-GAL4 adult female Drosophila eyes crossed to the indicated RNAi lines (superscript) or lacZ control. Inhibition of autophagy at any step of the process results in enhanced overgrowth of RasV12-expressing eyes. (b) Schematic of the autophagy pathway. Genes that knockdown enhances Ras-driven overgrowth are highlighted in green, with those identified in the RasV12-cooperative tumour suppressor primary screen circled in red. Scale bars: 100 μm.