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. 2017 Jun 5;36(40):5576–5592. doi: 10.1038/onc.2017.175

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Low expression of GABARAP and VAMP2 is prognostic for worse survival in KRAS-G12-positive PAAD. Survival curves of PAAD patients with low (black) or high (red) expression of GABARAP (a) and VAMP2 (b). Low expression of GABARAP (c) or VAMP2 (d) correlates with worse clinical outcome in patients (a and b) and with enrichment for G12-activating mutations in KRAS (e and f), suggesting that these autophagy-related genes behave as tumour suppressors in PAAD with KRAS-activating mutations. Statistics: Fisher’s exact t-test.