Table 1. Autophagy-related genes in Drosophila and their corresponding human orthologues.

Autophagy step	Drosophila gene	CG no.	Human orthologue	Molecular function
Induction	Atg1	CG10967	ULK1, ULK2	Kinase
	Atg101	CG7053	ATG101	Protein binding
	Atg13	CG7331	ATG13	Protein kinase binding
	Atg17/FIP200	CG1347	RB1CC1	Protein kinase binding
Nucleation	Atg6	CG5429	BECN1	Protein binding
	Atg14	CG11877	ATG14	Protein binding
	Vps15/ird1	CG9746	PIK3R4	Kinase
	Vps34/Pi3K59F	CG5373	PIK3C3	Kinase
	Atg18a	CG7986	WIPI2	PIP2 binding
	Atg9a	CG3615	ATG9A, ATG9B	Protein binding
	Atg2	CG1241	ATG2A, ATG2B	Protein binding
Elongation	Atg3/Aut1	CG6877	ATG3	Ubiquitin-like ligase
	Atg4a	CG4428	ATG4A, ATG4B	Cysteine-type endopeptidase
	Atg4b	CG6194	ATG4C	Cysteine-type endopeptidase
	Atg7a	CG5489	ATG7	Ubiquitin-activating enzyme
	Atg8aa	CG32672	GABARAP	Ubiquitin-like
	Atg8b	CG12334	MAP1LC3C, MAP1LC3B2	Ubiquitin-like modifying enzyme
Completion	Atg10	CG12821	ATG10	Ubiquitin-like ligase
	Atg12	CG10861	ATG12	Ubiquitin-like
	Atg5	CG1643	ATG5	Ubiquitin-like ligase
	Atg16	CG31033	ATG16L1, ATG16L2	Ubiquitin-like ligase
Fusion to the lysosome	Syx17a	CG7452	STX17	SNAP/SNARE protein binding
	Vamp7a	CG1599	VAMP7, VAMP8	SNARE protein binding
	Snap29/usnpa	CG11173	SNAP29	SNAP receptor
	nSyba	CG17248	VAMP1, VAMP2, VAMP3	SNARE protein binding

^aBold Italics indicate genes identified in a screen for Ras-cooperative tumour suppressor genes.