Table 4.
Main study outcomes for entire study cohort.
| Study [ref], year | N | Duration of follow up | Coronary Revascularisation rates | End point | No of events | HFABP cut off for analysis | Events in ‘lower’ HFABP/total in group | Events in ‘higher’ HFABP/total in group | Unadjusted risk for ‘higher’ HFABP levels | Adjusted risk for ‘higher’ HFABP levels | Covariates used |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Reiter [9] 2013 | 1074 | 12 months | Not specified | Death | - | 5.76µg/L. | - | - | - | aHR 1.017 (1.007 – 1.029) p = 0.002 | Age, gender, cardiovascular risk factors |
| Viswanathan [12] 2010 | 955 | >12 months | 8.1%(inpatient revascularisation noted only) | Death or MI | 96 | 6.48µg/l | 48/838 | 48/117 | uRR 7.16 (5.05-10.17) p<0.0001 uOR 11.45 (7.16-18.31) p <0.0001 |
aHR 2.62 (1.3-5.28) p = 0.007 | Age, DM, HTN, previous HF, previous MI, admission HR, ST Depression, Creatinine, Tn |
| McCann [11] 2009 | 550 | 12 months | PCI 38% CABG 8% |
Death | 29 | 5µg/l | - | - | uOR 21.2 (2.9 – 157.3) p = 0.003 | aOR 10.5 (1.4-80.6) p=0.023 |
Age, gender, risk factors, cardiac history, SBP, Killip class, ECG, eGFR, WCC, Tn, investigational biomarkers. |
| Death or MI | 54 | uOR 5.4(2.4-12.2) p<0.001 | aOR 2.7 (1.1-6.4) p = 0.028 | ||||||||
| MI | 31 | Not significant | Not significant | ||||||||
| Ilva [14] 2008 | 293 | 6 months | Not specified | Death or MI | 43 | 10.4µg/l | 18/183 | 25/110 | uRR* 2.31 (1.32-4.04) p = 0.0033 uOR* 2.7 (1.39 – 5.22 p = 0.0032 |
Not significant | Age, gender, DM, Chol, HTN, Smoker, prev MI, Prev revasc, Killip Class, ST deviation, Tn. |
| Kilcullen [7] 2007 | 1448 | 12 months | PCI 7.4% CABG 2.6% (both inpatient revascularisation noted only) |
Death | 296 | 5.8µg/l | 11/305 | 285/1143 | uRR* 6.91 (3.84 – 12.46) p < 0.0001 uOR* 8.88 (4.79 – 16.45) p <0.0001 |
- | |
| O’Donoghue [13] 2006 | 2287 | 30 days | PCI for index event 33.9% | MI | - | 8µg/l | - | - | uHR 1.9 (1.04-3.4) p=NR |
- | Demographics, clinical characteristics, time to randomisation, index diagnosis, creatinine clearance, ST deviation, Biosite Tn |
| 10 months | Death | 102 | 61/1955 | 41/332 | uHR 4.1 (2.6-6.5) p<0.001 | aHR 2.7 (1.5-4.9) p=NR |
|||||
| 10 months | MI | 140 | 109/1955 | 31/332 | uHR 1.6 (1-2.5) p=0.053 | - | |||||
| Ishii [10], 2005 | 328 | 30 days | PCI 55.5% CABG 5.2% |
Cardiac death | 14 | 9.8µg/l | 1/164 | 13/164 | uRR* 13 (1.72 – 98.24) p = 0.0129 uOR* 14.03 (1.81 – 108.57) p = 0.0114 |
- | Age, gender, time from chest pain, STEMI, Tn, Creatinine, Killip class, Anterior AMI, previous MI. |
| 30 days | Death or MI | 18 | 3/164 | 15/164 | uRR* 4.7 (1.38 – 16.03) p = 0.0136 uOR* 5.42 (1.53 – 19.03) p = 0.0087 |
- | |||||
| 6 months | Cardiac death | 15 | 1/164 | 14/164 | uRR 14.5 (1.91 – 110.5) p = 0.009 | aRR 8.92 (1.15 – 69.4) p = 0.04 | |||||
| 6 months | Death or MI | 25 | 3/164 | 22/164 | uRR 7.7 (2.3 – 25.7) p = 0.0009 |
aRR 8.96 (2.64 – 30.4) p = 0.0004 | |||||
| 6 months | MI | 10 | 2/164 | 8/164 | uRR* 4 (0.86-18.55) p=0.076 |
*Calculated by author using raw data. - = Not reported.