Fig. 2.

PP13 (LGALS13) DNA and protein

(A) The configuration of LGALS13 made of 4 exons (E1-E4). The 3′ and 5′ ends are shown. Intronic and exonic mutations are marked. Note the − 98 promoter variants (with A and C nucleotides) and the thymidine deletion in position 221 (221 delT) of the open reading frame. (B) Exon construction of the wild type PP13 protein and the truncated variant (221 delT) protein that was used for expression experiments.

Modified from Huppertz et al., Ref. [94], and from Sammar et al., Ref. [125].