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. 2017 Oct 10;4(5):ENEURO.0332-16.2017. doi: 10.1523/ENEURO.0332-16.2017

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Copyright © 2017 Allen et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 8. — Inactivation of Ca_V2.2 currents in sympathetic neurons is indistinguishable in Δ18a-only and +18a-only mice. A, Averaged, normalized, steady-state inactivation curves generated from sympathetic neurons from Δ18a-only and +18a-only mice. Recordings were performed in the presence of ω-agatoxin IVA (50 nM), and isradipine (10 μM) to block Ca_V2.1 and Ca_V1 currents, respectively. Ca_V2.2 currents were inactivated by 3-s prepulses to different membrane voltages (between -90 and + 20 mV in 10-mV increments) and then currents evoked by 25-ms test pulses to 20 mV to measure Ca_V2.2 channel availability. Curves were fit by Boltzmann functions and V_1/2 values estimated. B, V_1/2 values from individual cells (open symbols), mean (filled symbol), median (horizontal line), 25th-75th interquartile range (box), and whiskers (range). Mean (median) values ± SE in mV were for Δ18a-only: -22.5 (-26.1) ± 4.3, and e18a-only mice: -20.1 (-22.7) ± 4.5.