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Influence of p66shc on myocardial function, IR injury and cardioprotection in vitro. (A) Left ventricular developed pressure (LVDP) at the end of reperfusion in % of that at the end of the stabilization period in wildtype (WT) and p66shc knockout (p66 KO) mice undergoing ischemia/reperfusion (IR) or ischemic preconditioning (IPC). (B) Infarct size (in % of left ventricle) in WT and p66shc-KO mice subjected to IR or IPC.
