Table 1.
The HCC rate and nontoxicity of butaselen in mice models at the 24th week.
| Groups | No. | HCC (%) | Liver/body weight (%) | Thymus/body weight (%) | Spleen/body weight (%) | WBC (× 109/L) | RBC (× 1012/L) | PLT (× 109/L) |
|---|---|---|---|---|---|---|---|---|
| Control | 10 | 0 | 5.17 ± 0.22 | 0.25 ± 0.02 | 0.27 ± 0.06 | 7.10 ± 1.52 | 9.76 ± 0.55 | 685.40 ± 37.58 |
| Model | 10 | 80 | 8.18 ± 0.39* | 0.13 ± 0.04* | 0.54 ± 0.12* | 15.20 ± 3.73* | 8.34 ± 0.41* | 506.60 ± 57.40* |
| BSL | 10 | 40 | 7.03 ± 0.53*# | 0.16 ± 0.03* | 0.44 ± 0.11* | 13.26 ± 3.4* | 9.06 ± 0.12 | 523.40 ± 38.96* |
| BSM | 10 | 20 | 6.18 ± 0.46*# | 0.19 ± 0.03*# | 0.32 ± 0.07# | 12.78 ± 3.06* | 9.13 ± 0.36 | 615.50 ± 34.29# |
| BSH | 10 | 10 | 5.65 ± 0.38# | 0.22 ± 0.04# | 0.29 ± 0.04# | 9.80 ± 1.82# | 9.15 ± 0.62# | 631.40 ± 25.22# |
Data were shown as mean ± std, n ≥ 6 and analyzed with One-way ANOVA. *, #p < 0.05 compared with control group or model group. BSL, 9 mg/kg BS; BSM, 18 mg/kg BS; BSH, 36 mg/kg BS. WBC, white blood cells; RBC, red blood cells; PLT, platelet.