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Gene Modification of Human HSPCs
| Transduction | Control |
sCD4 |
||
|---|---|---|---|---|
| CD34+ Cells (%) | ZsGreen1+ Cells (%) | CD34+ Cells (%) | ZsGreen1+ Cells (%) | |
| 1 | 94 | 43 | 90 | 23 |
| 2 | 97 | 41 | 95 | 33 |
| 3 | 93 | 28 | 94 | 13 |
| Mean ± SEM | 95 ± 1 | 37 ± 5 | 93 ± 2 | 23 ± 6 |
HSPCs isolated from human UCB were transduced with LV-EF1α (control) or LV-EF1α-AAT-CD4 (sCD4). The cells were analyzed for the presence of CD34 and the percentage of ZsGreen1+ cells within the CD34+ cell population on day 1 post-transduction.
