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. 2017 Oct 10;36:139. doi: 10.1186/s13046-017-0609-y

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — Elevated expression of Par3 promotes PCa metastasis via Hippo pathway inactivation. In PCa, Elevated expression of Par3 enhances its interaction with KIBRA to form a Par3/aPKC/KIBRA complex so to dissociate KIBRA/Merlin/FRMD6 complex. As a result, the interaction of KIBRA with LATS is attenuated and phosphorylation of LATS and downstream YAP is decreased to enhance the nuclear translocation of YAP, which promotes transcription of several pro-metastatic genes by conjunction of YAP with TEAD transcription factors. p: phosphorylation