Table 2.
Comparison of human AKT1 with RAC/AKT kinases from different origins. Identity and similarity percentages of the full protein as well as percentages of similarity in the distinct domains are shown. Sequence alignment was performed using the Needleman-Wunsch algorithm
| Species | Identity | Similarity | |||
|---|---|---|---|---|---|
| Full Protein | Full Protein | PH Domain | Kinase Domain | AGC Domain | |
| H. sapiens | 100 | 100 | 100 | 100 | 100 |
| M. musculus | 98.3 | 99.0 | 99.0 | 99.6 | 97.2 |
| C. familiaris | 96.9 | 98.3 | 100 | 99.2 | 93.1 |
| D. melanogaster | 48.6 | 60.5 | 71.3 | 88.4 | 62.3 |
| S. mansoni | 47.9 | 58.5 | 74.0 | 81.5 | 52.6 |
| C. elegans | 51.8 | 65.8 | 72.1 | 83.0 | 60.3 |
| D. discoideum | 41.5 | 58.5 | 43.9 | 72.7 | 46.7 |
| E. histolytica | 37.5 | 56.0 | 45.8 | 70.3 | 41.8 |
| L. mexicana | 26.3 | 43.0 | 28.9 | 61.7 | 36.8 |
| L. braziliensis | 26.8 | 42.1 | 28.7 | 61.7 | 21.7 |
| L. infantum | 26.3 | 42.8 | 29.8 | 61.7 | 29.6 |
| L. major | 26.0 | 41.9 | 26.0 | 61.7 | 29.6 |
| L. donovani (India) | 26.5 | 43.2 | 29.8 | 61.7 | 29.6 |
| L. donovani (Nepal) | 26.3 | 42.8 | 29.8 | 61.7 | 29.6 |
| L. panamensis | 35.0 | 55.0 | 43.0 | 63.0 | 19.3 |
| T. cruzi | 33.0 | 52.6 | 42.0 | 64.6 | 37.2 |
| T. brucei | 32.7 | 50.9 | 36.8 | 63.6 | 41.0 |
| T. vivax | 34.7 | 54.3 | 42.3 | 64.8 | 45.2 |
| T. rubrum | 25.9 | 38.2 | 3.0 | 69.3 | 43.4 |
| G. intestinalis | 27.2 | 41.1 | 14.9 | 58.0 | 38.4 |
| P. yoelii | 23.2 | 35.0 | 3.9 | 71.8 | 50.0 |
| P. falciparum | 23.1 | 34.8 | 6.7 | 74.5 | 45.3 |