Table 4.
Meta-analysis on allelic associations of IL23R–IL12RB2 SNPs
| SNP | Phase | BD cases, risk allele/total | Controls, risk allele/total | Weight % | I 2 % | OR (95% CI) | P |
|---|---|---|---|---|---|---|---|
| rs1495965 | Dis. | 467/738 (63) | 2203/4000 (55) | 83.7 | 35 | 1.41 (1.20, 1.65) | 0.000049 |
| Rep. | 106/168 (63) | 272/566 (48) | 16.3 | 1.85 (1.30, 2.63) | 0.00060 | ||
| Total | 573/906 (63) | 2475/4566 (54) | 1.47 (1.27, 1.70) | 0.00000025 | |||
| rs4655535 | Dis. | 467/738 (63) | 2201/4000 (55) | 83.7 | 27 | 1.41 (1.20, 1.66) | 0.000033 |
| Rep. | 107/168 (64) | 277/566 (49) | 16.3 | 1.83 (1.28, 2.61) | 0.00080 | ||
| Total | 574/906 (63) | 2478/4566 (54) | 1.47 (1.27, 1.71) | 0.00000026 | |||
| rs1495966 | Dis. | 467/738 (63) | 2204/4000 (55) | 83.4 | 0 | 1.40 (1.19, 1.64) | 0.000038 |
| Rep. | 106/168 (63) | 264/548 (48) | 16.6 | 1.84 (1.29, 2.62) | 0.00070 | ||
| Total | 573/906 (63) | 2464/4548 (54) | 1.47 (1.27, 1.70) | 0.00000029 | |||
| rs1966176 | Dis. | 506/738 (69) | 2443/4000(61) | 83.6 | 5 | 1.39 (1.18, 1.64) | 0.00011 |
| Rep. | 118/168 (70) | 322/562 (57) | 16.4 | 1.76 (1.21, 2.55) | 0.0026 | ||
| Total | 624/906 (69) | 2765/4562 (61) | 1.45 (1.24, 1.69) | 0.0000021 | |||
| rs6665569 | Dis. | 465/738 (53) | 2210/4000 (55) | 83.0 | 0 | 1.38 (1.17, 1.62) | 0.000094 |
| Rep. | 103/168 (61) | 271/550 (49) | 17.0 | 1.63 (1.15, 2.32) | 0.0063 | ||
| Total | 568/906 (63) | 2481/4550 (55) | 1.42 (1.23, 1.65) | 0.0000030 | |||
| rs924080 | Dis. | 590/738 (80) | 2940/4000 (74) | 86.4 | 62 | 1.44 (1.18, 1.74) | 0.00022 |
| Rep. | 143/168 (85) | 413/566 (73) | 13.6 | 2.12 (1.33, 3.37) | 0.0013 | ||
| Total | 733/906 (81) | 3353/4566 (73) | 1.53 (1.28, 1.83) | 0.0000032 | |||
| rs6677188 | Dis. | 590/738 (80) | 2937/4000 (73) | 85.8 | 34 | 1.44 (1.19, 1.75) | 0.00019 |
| Rep. | 142/168 (85) | 419/566 (74) | 14.2 | 1.92 (1.21, 3.03) | 0.0049 | ||
| Total | 732/906 (81) | 3356/4566 (73) | 1.51 (1.26, 1.80) | 0.0000060 |
SNP single-nucleotide polymorphism, BD Behçet’s disease, CI confidence interval, Dis. discovery phase, OR odds ratio, Rep. replication phase