Figure 7.

A simplified two-dimensional representation of GR binding one of its target semi-palindromic sequences (from PDB entry 3g9o). This figure does not attempt to represent the complexities seen in the full three-dimensional crystal. (a) Since the palindrome is imperfect, GR has two binding modes. (b) In the asymmetric unit, the two binding modes are effectively superimposed, causing alternate base identities at locations where the palindrome is imperfect. (c) R factors for refinements of PDB entry 3g9p. Examples of individual base pairs with electron density are shown in Supplementary Fig. S15.