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. Author manuscript; available in PMC: 2018 Apr 15.
Published in final edited form as: J Immunol. 2017 Mar 6;198(8):3029–3032. doi: 10.4049/jimmunol.1601824

Figure 5. Placental type I IFN regulates viral transmission to the placenta and fetus.

Figure 5

ifnar+/− females were bred with ifnar−/− males. Pregnant mice were infected with MHV68 at E8.5, and embryos were collected and genotyped at E15. Representative samples of embryonic genotypes from IFNAR−/− embryos (single band) or IFNAR+/− embryos (double band) and associated viral titers in their respective placentas (A) and fetuses (B). Viral titers from homozygous ifnar−/− and heterozygous ifnar+/− embryos. IFNAR−/− embryos have higher viral titers even when the mother is a heterozygote (n=5–7).