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. Author manuscript; available in PMC: 2017 Oct 10.
Published in final edited form as: Trends Immunol. 2016 Jul 8;37(8):546–556. doi: 10.1016/j.it.2016.06.004

Figure 2. Clonal development of innate-like T cells is impacted by chronic antigen exposure and cytokine environment.

Figure 2

Subsequent to an initial antigen encounte r (yellow) facilitated by antigen-presenting cells (APCs), some na·ive T cells evolve into memory T cells (blue) . With chronic antigenic TCR stimulation and/or the presence of cytokines including IL-15 (red), specific T cell clones (light purple) within the pool of memory T cells may either develop characteristics of innate-like T cells (dark purple) or remain conventional memory T cells. Changes in the innate T cell potential are depicted by the purple colored shading of the vertical bar.