Table 2.
mRNAs associated with AML survival.
| Gene symbol | Beta | HR | 95%CI (low) | 95%CI (high) | P-value |
|---|---|---|---|---|---|
| Risky mRNAs (top 20) | |||||
| POLR3C | 1.299177 | 3.666278842 | 1.822439 | 7.375612 | 0.00027 |
| TULP2 | 1.271691 | 3.56687887 | 1.659339 | 7.667284 | 0.001126 |
| CIRBP | 1.212915 | 3.363273616 | 1.676527 | 6.747048 | 0.000638 |
| WNT7A | 1.13283 | 3.104429621 | 1.563505 | 6.164025 | 0.001207 |
| FARS2 | 1.128418 | 3.090761914 | 1.589044 | 6.011672 | 0.000886 |
| HSBP1L1 | 1.101514 | 3.008717605 | 1.49912 | 6.038464 | 0.001941 |
| SPATA24 | 1.093419 | 2.984460963 | 1.507142 | 5.909864 | 0.001708 |
| GTSF1 | 1.088786 | 2.97066512 | 1.516522 | 5.81914 | 0.001504 |
| LOC150197 | 1.087166 | 2.965857274 | 1.512986 | 5.813873 | 0.001547 |
| PRR4 | 1.085033 | 2.959538025 | 1.426825 | 6.138709 | 0.003558 |
| ZSCAN16 | 1.059951 | 2.886230787 | 1.496316 | 5.567227 | 0.001565 |
| tAKR | 1.057348 | 2.878727159 | 1.41916 | 5.83942 | 0.003389 |
| TMCO6 | 1.048799 | 2.854219977 | 1.445137 | 5.637231 | 0.002525 |
| GLRA1 | 1.046813 | 2.848559639 | 1.431752 | 5.667387 | 0.002858 |
| KCNQ5 | 1.040786 | 2.83144076 | 1.412616 | 5.675325 | 0.003349 |
| CCDC61 | 1.030272 | 2.801828015 | 1.446379 | 5.427514 | 0.002258 |
| METRN | 1.014433 | 2.757800065 | 1.305514 | 5.825647 | 0.007844 |
| HIST2H2BF | 1.012048 | 2.751231083 | 1.452881 | 5.209838 | 0.001892 |
| RTN4R | 1.011228 | 2.748975915 | 1.384951 | 5.456416 | 0.003839 |
| PKP3 | 1.008338 | 2.741042689 | 1.428346 | 5.26015 | 0.002429 |
| Protective mRNAs (top 20) | |||||
| SPIC | −1.31893 | 0.2674205 | 0.129581 | 0.551884 | 0.00036 |
| ZBTB2 | −1.27059 | 0.2806665 | 0.142188 | 0.554012 | 0.00025 |
| VCAM1 | −1.26516 | 0.2821953 | 0.142927 | 0.557167 | 0.000267 |
| AMPD1 | −1.21566 | 0.2965143 | 0.147273 | 0.59699 | 0.000662 |
| SOX9 | −1.19687 | 0.3021391 | 0.15331 | 0.595449 | 0.000545 |
| CXCL10 | −1.18323 | 0.306289 | 0.146201 | 0.641673 | 0.001714 |
| MOCS1 | −1.17538 | 0.3087017 | 0.155751 | 0.611851 | 0.000759 |
| CXCL12 | −1.16587 | 0.3116504 | 0.159361 | 0.60947 | 0.000657 |
| SDC3 | −1.14539 | 0.3181006 | 0.16393 | 0.617262 | 0.000708 |
| SDC1 | −1.14055 | 0.3196427 | 0.161413 | 0.632981 | 0.001068 |
| FER1L4 | −1.12792 | 0.3237057 | 0.160942 | 0.651075 | 0.001558 |
| TRIM25 | −1.12791 | 0.32371 | 0.161198 | 0.650058 | 0.00152 |
| EBF3 | −1.1233 | 0.3252052 | 0.169878 | 0.622555 | 0.000698 |
| CDH15 | −1.11564 | 0.3277049 | 0.15995 | 0.671401 | 0.002299 |
| CD163L1 | −1.10857 | 0.3300322 | 0.16721 | 0.651404 | 0.001396 |
| IGF1 | −1.10036 | 0.3327518 | 0.171385 | 0.646052 | 0.001152 |
| ADAMTS9 | −1.07894 | 0.3399546 | 0.174127 | 0.663706 | 0.001573 |
| C10orf81 | −1.0656 | 0.34452 | 0.172913 | 0.686437 | 0.002448 |
| ZCCHC24 | −1.06124 | 0.3460263 | 0.172931 | 0.692381 | 0.00271 |
| CCL18 | −1.04882 | 0.3503516 | 0.180175 | 0.681262 | 0.001993 |
HR – hazard ration; CI – confidence interval; Beta – regression coefficient; AML – acute myeloid leukemia.