Table 2.
Subclinical Brain Lesions and Mortality
| MRI Marker | All | Vascular | Nonvascular | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No. of Events | Rate (/1000 PYS) | HR (95% CI)a | P Value | No. of Event | Rate (/1000 PYS) | HR (95% CI)a | P Value | No. of Event | Rate (/1000 PYS) | HR (95% CI)a | P Value | |
| Per SD of ln(WMHV, 1/TIV%) | 244 | 24.7 | 1.3 (1.1–1.4) | 0.001 | 86 | 8.7 | 1.3 (1.1–1.7) | 0.017 | 134 | 13.6 | 1.2 (1.0–1.5) | 0.027 |
| WMHV, 1/TIV% | ||||||||||||
| Q1 (n=322) | 28 | 10.9 | Ref. | 8 | 3.1 | Ref. | 19 | 7.4 | Ref. | |||
| Q2 (n=321) | 44 | 18.0 | 1.6 (1.0–2.5) | 0.071 | 11 | 4.5 | 1.2 (0.5–3.1) | 0.661 | 24 | 9.8 | 1.3 (0.7–2.5) | 0.344 |
| Q3 (n=322) | 66 | 26.3 | 1.5 (0.9–2.3) | 0.087 | 22 | 8.8 | 1.6 (0.7–3.7) | 0.255 | 40 | 16.0 | 1.5 (0.8–2.6) | 0.176 |
| Q4 (n=322) | 106 | 45.0 | 2.0 (1.3–3.1) | 0.004 | 45 | 19.1 | 2.6 (1.2–5.9) | 0.018 | 51 | 21.7 | 1.6 (0.9–2.9) | 0.107 |
| SBI | ||||||||||||
| No (n=1043) | 173 | 21.3 | Ref. | 55 | 6.8 | Ref. | 102 | 12.6 | Ref. | |||
| Yes (n=192) | 62 | 42.7 | 1.2 (0.9–1.6) | 0.343 | 28 | 19.3 | 1.6 (1.0–2.6) | 0.059 | 28 | 19.3 | 1.0 (0.6–1.5) | 0.826 |
CI indicates confidence interval; HR, hazard ratio; ln, natural log transformed; PYS, person‐years; Q, quartile; Ref., reference; SBI, subclinical brain infarction; TIV, total intracranial volume; WMHV, white matter hyperintensity volume.
a
HRs and 95% CIs were estimated using Cox proportional hazards models adjusted for age, sex, race/ethnicity, education, medical insurance status, body mass index, smoking, physical activity, moderate alcohol drinking, hypertension, diabetes mellitus, hypercholesterolemia, history of atrial fibrillation, coronary artery disease, and myocardial infarction.