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. 2017 Sep 7;6(9):e005086. doi: 10.1161/JAHA.116.005086

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© 2017 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Correlation between telomere length and ejection fraction. A, Cardiomyocyte telomere length distribution of nonfailing donors (NFDs) and patients with hypertrophic cardiomyopathy (HCM): HCM heart failure with preserved ejection fraction (HFpEF) and HCM heart failure with reduced ejection fraction (HFrEF). Black and red vertical lines are drawn at median value of the histogram obtained for NFDs and patients with HCM, respectively. Shifts in patients' telomeric length distribution median values are shown in brown and green horizontal lines for HCM HFpEF and HCM HFrEF, respectively. Wilcoxon rank sum analysis between NFDs and patients with HCM HFpEF and HCM HFrEF: P=0.004 and P=0.034, respectively. N indicates the number of cardiomyocytes scored (see also Table 3). The percentage of cells with short and long telomeres is shown in graphs. B, Boxplot analysis shows average telomere length measurements (per patient) between NFDs and patients with HCM HFpEF and HCM HFrEF (Kruskal‐Wallis test, P=0.164 and P=0.02, respectively). C, Distribution of telomere length (per patient) and cardiac function as measured by ejection fraction in NFDs (black circles), patients with HCM HFrEF (green triangles), and patients with HCM HFpEF (brown squares). Patients with shorter average telomere length are presented below the horizontal black line. A total of 20 NFD, 8 HCM HFpEF, and 9 HCM HFrEF patient samples with available ejection fraction data were analyzed. Q‐FISH indicates quantitative fluorescence in situ hybridization.