Table 1.
Subject Demographics and Aortic Dimensions
| All Subjects | Controls | TAV‐TAA | RL‐BAV | RN‐BAV | P Value |
|---|---|---|---|---|---|
| N | 56 | 245 | 210 | 60 | ··· |
| % female | 32 | 20 | 25 | 35 | 0.06 |
| Age (y), median (IQR) | 45 (32–52) | 61 (52–70)a | 50 (37–59)b | 47 (40–58)b | <0.001 |
| No AS | |||||
| N | 56 | 213 | 113 | 23 | ··· |
| % female | 32 | 22c | 24c | 52 | 0.01 |
| Age (y), median (IQR) | 45 (32–52) | 59 (49–69)a | 40 (33–52)b | 39 (33–44)b | <0.001 |
| SOV (cm), median (IQR) | ···d | 4.3 (4.0–4.6) | 4.0 (3.6–4.4)b | 3.9 (3.4–4.1)b | <0.001 |
| MAA (cm), median (IQR) | 3.2 (3.0–3.6)e | 4.0 (3.5–4.4)a | 3.7 (3.2–4.3)a, b | 3.7 (3.1–4.4)a | <0.001 |
| % with aortic dilatationf | 0 | 100 | 42 | 18 | ··· |
| Aortic insufficiency | |||||
| None (trace)/mild/moderate/severe/unavailable | ··· | 127/64/19/1/2 | 52/41/9/3/8 | 12/9/0/0/2 | |
| Mild AS | |||||
| N | ··· | 19 | 54 | 15 | ··· |
| % female | ··· | 16 | 24 | 27 | 0.77 |
| Age (y), median (IQR) | ··· | 67 (62–73) | 52 (46–62)b | 49 (42–58)b | <0.001 |
| SOV (cm), median (IQR) | ··· | 3.9 (3.6–4.0) | 4.1 (3.6–4.5) | 4.1 (3.6–4.3) | 0.47 |
| MAA (cm), median (IQR) | ··· | 4.3 (4.0–4.5) | 4.2 (3.8–4.6) | 4.0 (3.5–4.4) | 0.50 |
| % with aortic dilatationf | ··· | 100 | 24 | 20 | ··· |
| Aortic insufficiency | |||||
| None (trace)/mild/moderate/severe/unavailable | 9/7/2/1/0 | 18/16/14/2/4 | 6/7/1/1/0 | ||
| Moderate and severe AS | |||||
| N | ··· | 13 | 43 | 22 | ··· |
| % female | ··· | 8 | 30 | 23 | 0.24 |
| Age (y), median (IQR) | ··· | 67 (62–73) | 61 (52–65) | 58 (46–67) | 0.06 |
| SOV (cm), median (IQR) | ··· | 4.0 (3.6–4.4) | 3.8 (3.5–4.1) | 4.0 (3.8–4.2) | 0.10 |
| MAA (cm), median (IQR) | ··· | 4.2 (3.9–4.4) | 3.9 (3.4–4.4) | 4.1 (3.7–4.6) | 0.12 |
| % with aortic dilatationf | ··· | 100 | 37 | 14 | ··· |
| Aortic insufficiency | |||||
| None (trace)/mild/moderate/severe/unavailable | 2/6/4/0/1 | 20/16/4/1/2 | 13/6/3/0/0 | ||
AS indicates aortic stenosis; IQR, interquartile range; MAA, mid‐ascending aorta; RL‐BAV, right and left coronary leaflet fusion BAV; RN‐BAV, right and noncoronary leaflet fusion BAV; SOV, sinuses of Valslava; TAV‐TAA, tricuspid aortic valve with aortic dilation.
Significantly different vs controls.
Significantly different vs TAV‐TAA.
Significantly different vs RL‐BAV (note: no significances found for all subjects).
Significantly different vs RN‐BAV (Fisher exact test with Bonferroni correction).
No CE‐MRA available, SOV diameter inaccurate with the method described by Garcia et al.26
No CE‐MRA available, MAA diameter accurate with the method described by Garcia et al.26
Defined as either SOV or MAA diameter >4 cm.