Table 2.
Baseline Values and Changes of Arterial Parameters During the Study
| Variable | All Patients (N=161) | LDs (n=49) | DDs (n=112) | P Value | ECDs (N=52) | SCDs (n=60) | P Value |
|---|---|---|---|---|---|---|---|
| Baseline arterial parameters (at M3) | |||||||
| MBP, mm Hg | 98 (97–100) | 99 (96–102) | 98 (96–100) | 0.5 | 99 (96–102) | 97 (94–100) | 0.4 |
| PWV, m/s | 10.8 (10.5–11.2) | 11.2 (10.5–11.9) | 10.7 (10.3–11.0) | 0.4 | 10.6 (10.1–11.2) | 10.7 (10.2–11.2) | 0.7 |
| Carotid stiffness, m/s | 6.6 (6.4–6.8) | 6.7 (6.3–7.0) | 6.6 (6.3–6.9) | 0.5 | 6.8 (6.3–7.2) | 6.4 (6.0–6.8) | 0.2 |
| Carotid diameter, mm | 6.4 (6.2–6.5) | 6.2 (6.0–6.5) | 6.4 (6.3–6.4) | 0.2 | 6.6 (6.4–6.8) | 6.3 (6.1–6.5) | <0.05 |
| IMT, μm | 601 (586–616) | 583 (552–613) | 610 (593–627) | 0.1 | 622 (598–646) | 599 (575–623) | 0.2 |
| CWS, kPa | 70 (68–72) | 71 (66–75) | 70 (67–73) | 0.6 | 71 (67–75) | 69 (64–73) | 0.4 |
| Young's EM, kPa | 476 (441–512) | 466 (410–522) | 481 (436–527) | 0.8 | 508 (436–579) | 457 (398–517) | 0.4 |
| Variable | All Patients | LDs | DDs | P Value | ECDs | SCDs | P Value |
|---|---|---|---|---|---|---|---|
| Change in arterial parameters from M3 to M12 | |||||||
| MBP, mm Hg | −3 (−4 to −1)† | −4 (−7 to −1)* | −2 (−4 to 0)* | 0.3 | −3 (−0.6 to 0)* | −1 (−4 to 1) | 0.3 |
| PWV, m/s | −0.7 (−0.9 to −0.5)‡ | −1.4 (−1.8 to −1)‡ | −0.4 (−0.6 to 0.1)† | <0.001 | 0.1 (−0.4 to 0.4) | −0.7 (−1 to −0.4)‡ | <0.01 |
| Carotid stiffness, m/s | −0.2 (−0.4 to 0.0)* | −0.9 (−1.1 to −0.6)‡ | 0.1 (−0.2 to 0.3) | <0.001 | 0.1 (−0.2 to 0.4) | 0.1 (−0.3 to 0.4) | 0.7 |
| Carotid diameter, mm | −0.2 (−0.3 to −0.1)‡ | −0.4 (−0.5 to −0.3)‡ | −0.1 (−0.2 to 0)† | <0.001 | −0.1 (−0.2 to 0.1) | −0.2 (−0.3 to −0.1)‡ | 0.1 |
| IMT, μm | 17 (7–28)† | 44 (20–66)‡ | 6 (−6 to 17) | <0.001 | 1 (−13 to 16) | 10 (−8 to 27) | 0.5 |
| CWS, kPa | −6 (−8 to −4)‡ | −11 (−15 to −11)‡ | −3 (−6 to −1)† | <0.001 | −3 (−7 to 1) | −4 (−7 to 0)† | 0.8 |
| Young's EM, kPa | −47 (−79 to −14)† | −145 (−187 to −102)‡ | −2 (−43 to 38) | <0.001 | 6 (−52 to 65) | −10 (−68 to 48) | 0.7 |
Values are expressed as mean (95% confidence interval). CWS indicates circumferential wall stress; DDs, deceased donors; ECDs, extended criteria donors; EM, elastic modulus; IMT, intima‐media thickness; LDs, living donors; M3, month 3 after kidney transplantation; M12, month 12 after kidney transplantation; MBP, mean arterial blood pressure; PWV, pulse wave velocity; SCDs, standard criteria donors.
P: statistical difference between groups (LD:DD; ECD:SCD); *P<0.05, † P<0.01, and ‡ P<0.001 for change within groups.