Table 4.

Relationship Between Risk Factors and the Primary Composite Outcome (Cardiovascular Death, Nonfatal Myocardial Infarction, or Nonfatal Stroke) in the Full Model (Model 3)

	χ2	df	P Value	HR (95% CI)
Characteristics
Polyvascular disease	58.243	1	<0.001	1.62 (1.43–1.84)
Age (as continuous variable)
Per 5 y, when age >65 y	55.186	1	<0.001	1.25 (1.18–1–32)
Per 5 y, when age ≤65 y	0.810	1	0.368	1.03 (0.97–1.09)
Renal dysfunction	46.275	1	<0.001	1.47 (1.32–1.64)
Diabetes mellitus	35.465	1	<0.001	1.40 (1.25–1.54)
Smoking (current vs never)	27.079	2	<0.001	1.48 (1.26–1.73)
HDL cholesterol (as continuous variable)
Per 0.5 mmol/L, when HDL <1.4 mmol/L	8.815	1	0.003	0.81 (0.71–0.93)
Per 0.5 mmol/L, when HDL ≥1.4 mmol/L	3.228	1	0.072	1.16 (0.99–1.37)
Female sexa	6.199	1	0.013	0.83 (0.71–0.96)
Region of enrollment (ref. Western Europe)	8.226	4	0.084
Asia/Pacific				1.05 (0.88–1.24)
Eastern Europe				1.14 (0.98–1.33)
North America				0.99 (0.85–1.15)
South America				1.26 (1.03–1.54)
Randomized treatment (darapladib vs placebo)	2.285	1	0.131	0.92 (0.83–1.02)

CI indicates confidence interval; df, degress of freedom; HDL, high‐density lipoprotein; HR, hazard ratio; ref., referent; χ², chi‐square.

^aIn addition to the variables listed in the table, this model also included psychosocial characteristics (marital and work status; whether patients were living alone; frequency of stress at work and financial stress; and frequency of depressive symptoms). For all variables except sex, the results are from a multivariable model including the interaction between sex and feeling down/depressed (p‐value for that interaction = 0.041). The results for sex are from the same multivariable model excluding the interaction term. The interaction between sex and feeling down or depressed with respect to the primary outcome is displayed in Figure 2.