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. 2017 Sep 27;4(10):756–761. doi: 10.1002/acn3.451

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© 2017 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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The majority of the antibody‐secreting cells in the cerebrospinal fluid (CSF) of MS patients express the IgG1 isotype. (A) After excluding debris and doublets (not shown), mononuclear cells in blood and CSF were gated for the expression of CD19, C27, and CD38, and assayed for the expression of IgG and IgG1. (B) The frequencies of B cells, of antibody‐secreting cells among B cells, and of antibody‐secreting cells expressing IgG1 in blood and CSF are shown (n = 29, Wilcoxon signed‐rank test). Results are presented as box plot diagrams with median, upper and lower quartile, and minimum/maximum values.