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. 2017 Oct 4;12:7255–7272. doi: 10.2147/IJN.S136726

Figure 6.

Figure 6

An illustration of endocytotic pathway of CLD/siRNA and CLD/cRGD-siRNA.

Note: The results demonstrated that CLD/cRGD-siRNA nanocomplexes could regulate the cellular pathways, which was contributed to ameliorate the intracellular fates and realize the highly efficient target of mRNA inhibition.

Abbreviations: CLD, cationic lipid material; siRNA, small interfering RNA; cRGD, cyclo(Arg-Gly-Asp-d-Phe-Lys[PEG-MAL]) peptide; CME, clathrin-mediated endocytosis; CvME, caveolae-mediated endocytosis.