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. 2017 Oct 9;7:12867. doi: 10.1038/s41598-017-12740-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Analysis of founder mouse #4. (A) Fibre-FISH showing presence of a wild type (WT), deletion (DEL) and duplication (DUP2) allele. (B) Meta and interphase-FISH with two colours; probes 1 + 4 (external) are green while probes 2 and 3 (internal) are red, confirming the DEL allele (red arrowheads). (C) Illustration of the structure of the duplication allele (DUP2) observed in this mouse. Sequence of the RV PCR band identified a 26 bp insertion from the bridge oligo (blue), 128 bp of Nox4 (grey) and a 6 bp deletion. The junction between the inverted duplicates is shown as a dotted line.