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. 2017 Oct 9;7:12839. doi: 10.1038/s41598-017-12943-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Multi-Dimensional Scaling (MDS) Component Plots for: Fetal Loss, Congenital Anomaly and Minor Congenital Anomaly. The three subplots on the left hand side of the figure (A,C,E) contain all drugs while on the right hand side of the figure (B,D,F) contain only drugs typically prescribed with legal termination. Red drugs are those shown as category D or X, blue drugs are category A or B while category C drugs are shown as grey. For all subplots, triangles indicate that the drug affected a protein encoded by a known Mendelian gene whereas circles indicate that the drug did not affect a protein encoded by a known Mendelian gene. For congenital anomalies, the proportion with an anomaly for each of the 5 exposure periods (2 pre-conception and 3 trimesters) were included as features. For fetal loss, only the 2 pre-conception periods and the first trimester were included.